ISSN: 2320-480X
Manuscript Submission

The Journal of Phytopharmacology 2023; 12(1):27-31 DOI:10.31254/phyto.2023.12104

Research Article

Protective effect of Spirulina platensis extract on aflatoxin B1 immunotoxicities in mice

Masese Johnson1 , Kipkoech Gilbert2 , Kimoloi Sammy3 , Mwitari Peter4 , Nguka Gordon5 , Mutai Charles6

1. School of Public Health, Biomedical Sciences and Technology, Masinde Muliro University of Science and Technology, P.O Box 190 – 50100, Kakamega Kenya
2. Department of Biochemistry, Biotechnology, Kenyatta University P.O Box 43844 - 00100, Nairobi, Kenya
3. Department of Medical Laboratory Sciences, School of Public Health, Biomedical Sciences and Technology, Masinde Muliro University of Science & Technology P.O Box 190 – 50100, Kakamega.
4. Centre for Traditional Medicine and Drug Research, Kenya Medical Research Institute (KEMRI), P.O. Box 54840 - 00200, Nairobi, Kenya
5. Department of Nutritions and diatetics, School of Public Health, Biomedical Sciences and Technology, Masinde Muliro University of Science & Technology P.O Box 190 – 50100, Kakamega, Kenya
6. Department of Medical Laboratory Sciences, School of Public Health, Biomedical Sciences and Technology, Masinde Muliro University of Science & Technology P.O Box 190 – 50100, Kakamega Kenya.

*Author to whom correspondence should be addressed.

Received: 8th January, 2023 / Accepted: 22nd February, 2023

Abstract


Aspergillus ?avus and Aspergillus parasiticus are the main Aspergillums species that form aflatoxins. Aflatoxins are hepatotoxic, teratogenic, carcinogenic and immunosuppressive. This study aimed to assess Spirulina platensis (S. platensis) extract inhibitory effect against aflatoxin B1 (AFB1) induced immunotoxicity in male Swiss albino mice. Twenty-five inbred weaned mice were randomly divided into five groups. Group I (Control group), were given routine diet. Treatments administered were: Group II (S. platensis extract 100 mg/kg/day), Group III (AFB1 200 µg/kg/day), Group IV (S. platensis extract 100 mg/kg/day and AFB1 200 µg/kg/day) and Group V (S. platensis extract 200 mg/kg/day and AFB1 200 µg/kg/day) for 28 consecutive days. Blood was aseptically collected and centrifuged to obtain serum. Quantitative determination of IgG, IgM and IgA in blood serum was done using ELIZA kits. One-way ANOVA data analysis was done. Post-hoc analysis was done using Tukey’s Honestly Significantly Differenced (HSD). P

Keywords


Spirulina platensis, Aflatoxin B1, Immune changes, Protective effects

HOW TO CITE THIS ARTICLE

Johnson M, Gilbert K, Sammy K, Peter M, Gordon N, Charles M.Protective effect of Spirulina platensis extract on aflatoxin B1immunotoxicities in mice. J Phytopharmacol 2023; 12(1):27-31. doi:10.31254/phyto.2023.12104

Creative Commons (CC) License-

This article is an open access article distributed under the terms and conditions of theCreative Commons Attribution (CC BY 4.0) license. This license permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited. (http://creativecommons.org/licenses/by/4.0/).

Copyright

Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0.

Technical Support

×